Amorphization of Pharmaceuticals by Co- grinding with Neusilin

Amorphization of crystalline drugs can be achieved through several methods. The most common method is melting and solidifi cation by rapid cooling over liquid nitrogen or slow cooling at room temperature. Other methods for drug amorphization include milling, solvent evaporation, spray drying, and lyophilization. Solid state amorphization can be achieved through high energy milling or co-grinding drugs with excipients leading to micronized particles with particle size distributions at submicron levels. These amorphous forms are in a higher energetic state compared to its crystalline counterpart and therefore, provide an advantage in terms of solubility, dissolution and bioavailability. Such amorphized forms of crystalline drugs leads to a marked improvement in their dissolution rates and bioavailability.